Check these links out for some interesting approaches to working with pixel drawings and low-res graphics:

http://psd.tutsplus.com/articles/techniques/learn-how-to-draw-hand-crafted-pixel-art-in-photoshop/

http://www.derekyu.com/?page_id=219

http://www.labnol.org/software/turn-images-into-pixel-art/12978/